David J Timson Selected Research

Uridine Diphosphate Galactose (UDP Galactose)

9/2016	The molecular basis of galactosemia - Past, present and future.
11/2014	The metastability of human UDP-galactose 4'-epimerase (GALE) is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding.
9/2013	Comparison of dynamics of wildtype and V94M human UDP-galactose 4-epimerase-A computational perspective on severe epimerase-deficiency galactosemia.
7/2013	In silico prediction of the effects of mutations in the human UDP-galactose 4'-epimerase gene: towards a predictive framework for type III galactosemia.
10/2012	Altered cofactor binding affects stability and activity of human UDP-galactose 4'-epimerase: implications for type III galactosemia.
10/2011	In vivo and in vitro function of human UDP-galactose 4'-epimerase variants.

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David J Timson Research Topics

Disease

21	Galactosemias (Galactosemia) 05/2021 - 04/2003
17	Neoplasms (Cancer) 05/2022 - 12/2007
8	Metabolic Diseases (Metabolic Disease) 02/2021 - 06/2014
6	Infections 01/2020 - 12/2009
6	Inborn Genetic Diseases (Disease, Hereditary) 01/2017 - 11/2003
5	Cataract (Cataracts) 05/2021 - 04/2003
3	Schistosomiasis (Bilharziasis) 01/2020 - 01/2016
2	Neoplasm Metastasis (Metastasis) 01/2017 - 02/2008
2	Breast Neoplasms (Breast Cancer) 01/2017 - 11/2009
1	Muscle Spasticity (Spastic) 05/2021
1	Disease Susceptibility (Diathesis) 01/2021
1	Brain Diseases (Brain Disorder) 01/2021
1	Hemorrhage 01/2021
1	Thalassemia 03/2020
1	Hemoglobinopathies 03/2020
1	Trematode Infections (Fasciolopsiasis) 01/2020
1	Paralysis (Palsy) 01/2020
1	Tay-Sachs Disease 01/2020
1	Multiple Sclerosis 07/2019
1	Nervous System Diseases (Neurological Disorders) 07/2019
1	Griscelli syndrome type 1 04/2019
1	Snyder Robinson syndrome 04/2019
1	Urinary Tract Infections (Urinary Tract Infection) 08/2018
1	Pneumonia (Pneumonitis) 01/2017
1	Primary Hyperoxaluria (Oxaluria, Primary) 01/2017
1	Colonic Neoplasms (Colon Cancer) 01/2017
1	Cattle Diseases (Bovine Diseases) 01/2017
1	Ovarian Neoplasms (Ovarian Cancer) 01/2017
1	Parasitic Diseases (Parasitic Disease) 01/2016
1	Mevalonate Kinase Deficiency 11/2015
1	Fever (Fevers) 11/2015
1	African Trypanosomiasis (Nagana) 08/2012
1	Dehydration (Water Stress) 11/2010
1	Fructose Intolerance (Intolerance, Fructose) 04/2010

Drug/Important Bio-Agent (IBA)

17	EnzymesIBA 02/2021 - 11/2003
14	Proteins (Proteins, Gene)FDA Link 05/2022 - 02/2008
12	Pharmaceutical PreparationsIBA 01/2020 - 10/2010
9	Galactose (Galactopyranose)FDA LinkGeneric 05/2021 - 03/2004
7	GalactokinaseIBA 03/2017 - 04/2003
6	NAD (NADH)IBA 08/2020 - 12/2007
6	quinone (benzoquinone)IBA 08/2020 - 12/2007
6	Uridine Diphosphate Galactose (UDP Galactose)IBA 09/2016 - 10/2011
5	Oxidoreductases (Dehydrogenase)IBA 08/2020 - 11/2014
4	Praziquantel (Biltricide)FDA Link 01/2020 - 01/2016
3	LigandsIBA 05/2022 - 02/2016
3	galactose-1-phosphateIBA 05/2021 - 11/2003
3	Amino Acids FDA Link 08/2020 - 01/2017
3	ProdrugsIBA 08/2020 - 02/2016
3	AntioxidantsIBA 08/2020 - 11/2014
3	Flavin-Adenine Dinucleotide (FAD)IBA 01/2017 - 11/2014
3	UDPglucose 4-Epimerase (UDP Galactose Epimerase)IBA 10/2012 - 02/2006
2	Oxygen (Dioxygen)IBA 05/2022 - 03/2020
2	CalciumIBA 01/2020 - 01/2018
2	Dicumarol (Dicoumarol)FDA Link 01/2017 - 12/2007
2	Albendazole (Albenza)FDA Link 10/2010 - 07/2010
1	Hydroxyl RadicalIBA 04/2021
1	CarbonIBA 04/2021
1	Transaminases (Aminotransferases)IBA 01/2021
1	Aldehyde Reductase (Aldose Reductase)IBA 05/2020
1	Messenger RNA (mRNA)IBA 05/2020
1	GlobinsIBA 03/2020
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 03/2020
1	Hemoglobins (Hemoglobin)IBA 03/2020
1	Hexosaminidase A (Hex A)IBA 01/2020
1	Myosins (Myosin)IBA 04/2019
1	Spermine SynthaseIBA 04/2019
1	ResveratrolIBA 01/2019
1	SugarsIBA 12/2018
1	Fosfomycin FDA Link 08/2018
1	Phosphotransferases (Kinase)IBA 08/2018
1	Anti-Bacterial Agents (Antibiotics)IBA 08/2018
1	Triose-Phosphate Isomerase (Triosephosphate Isomerase)IBA 06/2017
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2017
1	UDP-N-acetylgalactosamine polypeptide N-acetylgalactosaminyltransferase 6IBA 01/2017
1	Uridine Diphosphate (UDP)IBA 01/2017
1	Biomarkers (Surrogate Marker)IBA 01/2017
1	Mucin-1 (CA 15-3 Antigen)IBA 01/2017
1	Leucine (L-Leucine)FDA Link 01/2017
1	LipopolysaccharidesIBA 01/2017
1	ChemokinesIBA 01/2017
1	Actins (F Actin)IBA 01/2017
1	AcetylgalactosamineIBA 01/2017
1	Polypeptide N-acetylgalactosaminyltransferaseIBA 01/2017
1	Alanine-glyoxylate transaminase (alanine-glyoxylate aminotransferase)IBA 01/2017
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2017
1	mevalonate kinaseIBA 11/2015
1	Immunoglobulin D (IgD)IBA 11/2015
1	HydrocarbonsIBA 11/2010
1	benzimidazoleIBA 10/2010
1	Bovine Serum AlbuminIBA 07/2010
1	sulfoxideIBA 07/2010
1	TriclabendazoleIBA 07/2010
1	Fructose-Bisphosphate Aldolase (Aldolase)IBA 04/2010
1	FructoseIBA 04/2010
1	Protease Inhibitors (Protease Inhibitor)IBA 12/2009
1	Laminin (Merosin)IBA 11/2009
1	Superoxides (Superoxide)IBA 12/2007
1	UDPglucose-Hexose-1-Phosphate Uridylyltransferase (Galactose 1 P Uridyltransferase)IBA 11/2003

Therapy/Procedure

8	Therapeutics 05/2022 - 12/2007